Recent researches found that the south north gradient of the occurrence of multiple sclerosis is diminishing in the USA and doesn’t exist anymore in France.
Here are the two articles:
Alvaro Alonso, MD Miguel A. Herna ́n, MD
Temporal trends in the incidence of multiple sclerosis A systematic review
Neurology 71 July 8, 2008
Available in full text here:
Fromont A, Binquet C, Sauleau EA, Fournel I, Bellisario A, Adnet J, et al. Geographic variations of multiple sclerosis in France. Brain 2010;133:1889-99.OpenUrlAbstract/FREE Full Text http://brain.oxfordjournals.org/content/brain/133/7/1889.full.pdf
Thus the epidemiology of multiple sclerosis seems to shift toward a less intense south north gradient but in the same time an aggravation of the sex ratio, aggravating the burden that women bear in this inflammatory disease that affects the central nervous system (i.e. the central unit of our body in terms of information technologies).
This tendency opens new interests for more epidemiological studies in this field. All the more because the observational studies aiming to prove the mixed, genetic and environmental, etiology are entangled with the current migrations of populations, the mobility of young people in view of finding a job and the changes in life habits in the populations of the south such as using more protection against the sun rays.
Professor Confavreux had well depicted the stakes in this editorial:
An unchanging man faced with changing times Christian Confavreux
DOI: http://dx.doi.org/10.1093/brain/aws135 1663-1665 First published online: 24 May 2012
For the present moment multiple sclerosis etiological mechanism is an enigma and risks to remain so if researchers in the domain have no new data to crunch at the populational level.
Joel Kallich of Big Health Data wrote me: Over the last 30 years, the government has been reluctant to release identifiable information, first on an
via The value of identifiable research data.
Life is a permanent flow: one has to let go the past and present in order to authorize freely the next event of one’s life to happen. If not, a damp will interrupt the flow, which is not a good thing from a sound and balanced living perspective.
One has to live a life which is intrinsically ever changing, and thus which is anxiety provoking.
The only thing that is permanent is one’s awareness of being present in the present moment, which by itself is a blessing one should be grateful for .
At that point meditation, wether by focusing on an action like breathing or walking or by observing with detachment the course of our thoughts and feelings created by our mind or by exercising compassion and loving kindness towards other sentient beings can be of some help.
By the way it has been demonstrated by neuro-scientists that meditation modifies the way the brain functions and even the size of some brain regions.
I read an article on this subject in the November 2014 edition of the journal Scientific American entitled Mind of the Meditator, authored by Mathieux Ricard a Buddhist Monk, Antoine Lutz a research scientist at the Frenh National Institute of Health and Medical Research and Richard J Davidson from the University of Wisconsin-Madison.
They conclude that
“even with the requisite cautions, research on meditation provides new insights into methods of mental training that have the potential to enhance human health and well-being”
Here below is a link toward a time series published by the French Agency for pharmaceutical safety (aka ANSM). Although the method is well described and doesn’t raise any concern, nevertheless the interpretation that is done from the results in the discussion is subjected to caution.
My expression of concern is motivated by the fact that the authors of the study link the lowering of the incidence of pulmonary embolism to the lowering of sales of third and fourth generations of contraceptive pills.
Indeed a cofactor can explain the concomitant lowering of both time series:
the large warning campaign in the medias with messages about a) the risks attached to those third and fourth generations of contraceptive pills AND b) the risks of pulmonary embolism (ie blood clots in the lung) every woman faces under contraceptive pills, no matter the generation of the contraceptive pill.
Thus the practitioners could have been more attentive to the risk for all their patients and stopped the contraceptive pill, even for the first and second generation of pill, in case of any doubt (eg a phlebitis of the leg or a tobacco addiction).
One thing is for sure: the results of this study show that the campaign in the media had an impact in term of public health, but no causality can be formally drawn between the lowering of the sales of the third and fourth generations of contraceptive pills and the lowering of pulmonary embolism from the results of this study.
Etude de l’impact de la modification récente des méthodes de contraception sur la survenue d’embolies pulmonaires chez les femmes de 15 à 49 ans (07/11/2014) application/pdf (316 ko)