“we do a large trial and discover that, rather than preventing, we are causing”
This is the sentence written by searchers when disseminating their results. The Beta blockers in preventive use for patients who undergo surgery may have cause more harm than benefits. The searcher who first discovered their preventive effect has been fired from his university for fictitious data use and failure to obtain patient consent. Furthermore a randomized controlled trial shows an increase of overall mortality associated with Beta blockers systematic perioperative use. Like earlier for the menopausal hormonal replacement therapy, wide randomized controlled trials lead to reconsider previous beliefs in preventive effects. Any way, medical research has to continue in the sound interest of patients.